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KMID : 0980720090280010053
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Keimyung Medical Journal
2009 Volume.28 No. 1 p.53 ~ p.62
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Effect of Cisplatin on the Metabolism of the Reactive Oxygen Species in Kidney
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Baek Chul-Min
Kwak Chun-Sik
Ha Eun-Young
Kim You-Hee
Choi Hye-Jung
Hwang Eun-Ah
Park Sung-Bae
Kim Hyun-Chul
Mun Kyo-Cheol
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Abstract
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Cisplatin, an antitumor agent widely used in the treatment of a variety of human solid tumors, has nephrotoxicity. To understand the mechanism for the nephrotoxicity, oxidative stress markers levels and activities of antioxidative enzymes were measured. Sprague-Dawley rats received a single intraperitoneal injection of 8 mg/kg of cisplatin and sacrificed 6 days after cisplatin injection. When mitochondria was exposed to cisplatin, the oxygen free radical production was increased depending on the exposure time. Cisplatin treated rats showed the increase of hydrogen peroxide levels and xanthine oxidase activity in serum. However, catalase activity was decreased. The mRNA expression for renal superoxide dismutase was decreased in the cisplatin treated rats. These results suggest that cisplatin induces nephrotoxicity is
associated with the production of reactive oxygen species via the changes of the antioxidant enzymes.
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KEYWORD
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Cisplatin, Kidney, Reactive oxygen species
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